Abstract: Health disparities among young people based on sexual orientation and gender identity are not going away. Recent studies have shown the size of the disparity in suicide attempts has not shrunk over the past 20+ years. HIV diagnoses have been continuing to increase among young men who have sex with men (MSM), while they decline in many other groups. In this talk, Dr. Mustanski will describe his research examining multi-level drivers of health disparities among young MSM and his program of research that uses community-engaged methods to create, test effectiveness, and now study the implementation of eHealth approaches to HIV prevention. The talk will conclude with a model of the multilevel changes that will be necessary to allow sexual and gender minority youth to have an opportunity to attain their highest level of health.